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Reference: Hsieh et al., 2017 (VEGFR2AkteNOS signalling involvement) VEGFR2 activation triggers: VEGF binding VEGFR2 autophosphorylation (turns on VEGFR2) which leads to PI3K activation which leads to Akt phosphorylation Akt (Protein Kinase B) is critical because it phosphorylates (turns on) eNOS which leads to Nitric oxide synthesis more nitric oxide

(NCN 2013/11/B and NZ2/00130)

However, these can be painful, are difficult to give to disabled or elderly patients, and are costly if administered by health professionals [2]

Draw the prescribed amount into the syringe, then remove air bubbles